Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor.

  title={Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor.},
  author={Andrew W Roberts and Simon Foote and Warren S. Alexander and Clare H Scott and Lorraine Robb and Donald Metcalf},
  volume={89 8},
The mechanisms involved in the mobilization of progenitor cells into the blood by granulocyte colony-stimulating factor (G-CSF) and other cytokines are poorly understood. To identify important influences on this complex process, in vivo murine models were used. Granulocyte-macrophage colony-stimulating factor (GM-CSF) transgenic, Max41 transgenic, W/Wv, Mpl-null, GM-CSF receptor (beta chain)-null mice, wild-type littermate controls, and six inbred strains of mice were injected with 200 microg… CONTINUE READING
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