Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination.

Abstract

The immune-mediated central nervous system (CNS) demyelinating disorder multiple sclerosis (MS) is the most common neurological disease in young adults. One important goal of MS research is to identify strategies that will preserve oligodendrocytes (OLs) in MS lesions. During active myelination and remyelination, OLs synthesize large quantities of membrane… (More)
DOI: 10.1002/glia.22634

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Cite this paper

@article{Hussien2014GeneticIO, title={Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination.}, author={Yassir Hussien and Douglas R. Cavener and Brian Popko}, journal={Glia}, year={2014}, volume={62 5}, pages={680-91} }