Genetic inactivation of Ikaros is a rare event in human T-ALL.

@article{Marais2010GeneticIO,
  title={Genetic inactivation of Ikaros is a rare event in human T-ALL.},
  author={Ambroise Marçais and Robin Jeannet and Lucie Hernandez and Jean Soulier and François Sigaux and Szekwan Chan and Philippe Kastner},
  journal={Leukemia research},
  year={2010},
  volume={34 4},
  pages={
          426-9
        }
}
The Ikaros (Ikzf1) gene, encoding a transcription regulator, is a major tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL). In the mouse, however, loss of Ikaros is primarily associated with T-ALL development. Whether Ikaros is also implicated in human T-ALL remains unclear. We studied Ikaros in 25 human T-ALL samples from diverse molecular subtypes at the mRNA, protein, sequence and genomic copy number level. We found that Ikaros was abnormal in only one sample: one allele was… CONTINUE READING
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