Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal.

@article{Sebastian2011GeneticIO,
  title={Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal.},
  author={A. J. Balseyro Sebastian and Takehiko Matsushita and Aya Kawanami and Susan Mackem and Gary E. Landreth and Shunichi Murakami},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2011},
  volume={29 3},
  pages={
          375-9
        }
}
Activating mutations in FGFR3 cause the most common forms of human dwarfism: achondroplasia and thanatophoric dysplasia. In mouse models of achondroplasia, recent studies have implicated the ERK MAPK pathway, a pathway activated by FGFR3, in creating reduced bone growth. Our recent studies have indicated that increased Fgfr3 and ERK MAPK signaling in chondrocytes also causes premature synchondrosis closure in the cranial base and vertebrae, accounting for the sometimes fatal stenosis of the… CONTINUE READING
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