Genetic imbalances revealed by comparative genomic hybridization in Ewing tumors.

  title={Genetic imbalances revealed by comparative genomic hybridization in Ewing tumors.},
  author={Toshifumi Ozaki and Michael Paulussen and Christopher Poremba and Christian Brinkschmidt and J S Rerin and Susanne Ahrens and Christian Hoffmann and Axel Hillmann and D F Tang Wai and K. L. Schaefer and Werner Boecker and Heribert J{\"u}rgens and Wilfried Winkelmann and Barbara Dockhorn-Dworniczak},
  journal={Genes, chromosomes & cancer},
  volume={32 2},
Ewing tumors are characterized by reciprocal translocations involving the EWS gene on 22q12 fused to ETS transcription-factor family members. Little is known about further aberrations contributing to tumor development and progression. Sixty-two frozen tumors with known EWS rearrangements (52 primary tumors, 10 relapses) of ET patients registered in the EICESS protocol were analyzed by comparative genomic hybridization (CGH). The median number of changes in 52 primary and 10 relapsed cases was 2… CONTINUE READING


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