Genetic identification of a respiratory arsenate reductase.

@article{Saltikov2003GeneticIO,
  title={Genetic identification of a respiratory arsenate reductase.},
  author={Chad W. Saltikov and Dianne K Newman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 19},
  pages={10983-8}
}
For more than a decade, it has been recognized that arsenate [H2AsO41-; As(V)] can be used by microorganisms as a terminal electron acceptor in anaerobic respiration. Given the toxicity of arsenic, the mechanistic basis of this process is intriguing, as is its evolutionary origin. Here we show that a two-gene cluster (arrAB; arsenate respiratory reduction) in the bacterium Shewanella sp. strain ANA-3 specifically confers respiratory As(V) reductase activity. Mutants with in-frame deletions of… CONTINUE READING
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