Genetic hypercalciuric stone-forming rats have a primary decrease in BMD and strength.

@article{Grynpas2009GeneticHS,
  title={Genetic hypercalciuric stone-forming rats have a primary decrease in BMD and strength.},
  author={Marc D. Grynpas and Stephen D. Waldman and Douglas Holmyard and David A. Bushinsky},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2009},
  volume={24 8},
  pages={
          1420-6
        }
}
Kidney stone patients often have a decrease in BMD. It is unclear if reduced BMD is caused by a primary disorder of bone or dietary factors. To study the independent effects of hypercalciuria on bone, we used genetic hypercalciuric stone-forming (GHS) rats. GHS and control (Ctl) rats were fed a low Ca (0.02% Ca, LCD) or a high Ca (1.2% Ca, HCD) diet for 6 wk in metabolic cages. All comparisons are to Ctl rats. Urine Ca was greater in the GHS rats on both diets. GHS fed HCD had reduced cortical… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS

Modeling hypercalciuria in the genetic hypercalciuric stone-forming rat.

  • Current opinion in nephrology and hypertension
  • 2015
VIEW 14 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Idiopathic Hypercalciuria and Bone Health

  • Current Osteoporosis Reports
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

Osteoporosis update from the 2010 santa fe bone symposium.

  • Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
  • 2011
VIEW 1 EXCERPT
CITES BACKGROUND

Renal stone disease.

  • Nephron. Physiology
  • 2011

Similar Papers

Loading similar papers…