Genetic Heterogeneity of Icelanders
- Geography, MedicineAnnals of human genetics
An extensive reanalysis of mtDNA variation in Iceland by examining primary data from original sources on 26 European populations shows that Icelanders are among the most genetically heterogeneous Europeans by the mean number of nucleotide differences as well as by estimates of θ parameters of the neutral theory.
Genetic Diversity and Linkage Disequilibrium in the Polynesian Population of Niue Island
- Medicine, BiologyHuman biology
Niue Islanders are genetically isolated and have a homogeneous Southeast Asian ancestry that has reduced autosomal genetic diversity and high levels of linkage disequilibrium that are consistent with the influence of genetic drift mechanisms, such as a founder effect or bottlenecks.
The composition of the founding population of Iceland: A new perspective from 3D analyses of basicranial shape
- MedicinePloS one
Three-dimensional techniques used to compare the basicrania of skeletons from archaeological sites in Iceland, Scandinavia, and the British Isles yielded two main results, which strengthen the idea that the founding population of Iceland was a mix of Scandinavians and people from theBritish Isles and raise a new possibility regarding the regions from which the settlers originated.
Founder variations in isolated populations
This chapter outlines the reasons for their usefulness in genetic studies and describes the role they have played and continue to play in gene-mapping efforts and specific examples of gene identification are provided.
A Pre-Modern Nation? Icelanders' Ethnogenesis and Its Mythical Foundations
Þad er margra manna mäl ad þad sie uskilldur frodleikur ad rita Landnam. enn uier þikiunst helldur suara kunna utlendum monnum. þa er þeir bregda oz þui, ad uier sieum komner af þrælum eda illmennum,…
Icelanders as Subjects of Science
In this chapter I discuss plans that were made in Iceland to establish a database with health, genetic and genealogical data for the entire nation. I first describe these plans in some detail and…
Défis techniques, problèmes éthiques : repenser l'éthique de la recherche en génomique humaine à l'ère des infrastructures de recherche
Dans le champ de la recherche en genomique, comme dans d'autres domaines tres informatises, les bases de donnees et les biobanques sont organisees en infrastructures. Ce nouveau modele…
Ancient Celts: myth, invention or reality? Dental affinities among continental and non- continental Celtic groups
Dental anthropological study of the proto-Celts, and continental and non-continental Celtic tribes during the Iron Age, particularly its applicability in estimating biological affinities of these…
A Bold Experiment: Iceland’s Genomic Venture
In 2008, like an overheated nuclear reactor, Iceland’s banking sector melted down. After investors pulled money out of Iceland en masse, the Icelandic government took control over the last and…
SHOWING 1-10 OF 12 REFERENCES
mtDNA and the origin of the Icelanders: deciphering signals of recent population history.
- Biology, MedicineAmerican journal of human genetics
The findings indicate that European populations contain a large number of closely related mitochondrial lineages, many of which have not yet been sampled in the current comparative data set, and substantial increases in sample sizes will be needed to obtain valid estimates of the diverse ancestral mixtures that ultimately gave rise to contemporary populations.
Linkage disequilibrium mapping of complex disease: fantasy or reality?
- Biology, MedicineCurrent opinion in biotechnology
It is becoming clear that the prognosis of the current paradigm with regard to its robustness to the types of problems that are likely to exist needs to be re-evaluated.
Mitochondrial cytochrome b DNA sequence variation of Atlantic cod, Gadus morhua, from the Baltic and the White Seas.
- Biology, MedicineHereditas
We studied sequence variation of a fragment of the mitochondrial cytochrome b gene using polymerase chain reaction (PCR) and direct sequencing of 109 Atlantic cod (Gadus morhua) from the Baltic and…
Population Genomics: Laying the Groundwork for Genetic Disease Modeling and Targeting
- Biology, MedicineClinical chemistry and laboratory medicine
Basing the company in Iceland directly benefits the population in terms of employment and return on investment as well as providing the health care system with an information resource which may be used in preventive medicine and in the optimization of health care in Iceland.
Mapping of a familial essential tremor gene, FET1, to chromosome 3q13
- Biology, MedicineNature Genetics
The scan for FET genes in 16 Icelandic families with 75 affected individuals revealed one locus on chromosome 3q13 to which FET mapped with genome-wide significance when the data were analysed either parametrically or non-parametrically, assuming an autosomal dominant model.
A comprehensive genetic map of the human genome based on 5,264 microsatellites
- Biology, MedicineNature
The last version of the Généthon human linkage map is reported, which consists of 5,264 short tandem repeat polymorphisms with a mean heterozygosity of 70%.
Classification of European mtDNAs from an analysis of three European populations.
- Biology, MedicineGenetics
The conclusion that most haplogroups observed in Europe are Caucasoid-specific, and that at least some of them occur at varying frequencies in different Caucasoid populations, is supported.
Paleolithic and neolithic lineages in the European mitochondrial gene pool.
- Biology, GeographyAmerican journal of human genetics
It follows that the major extant lineages throughout Europe predate the Neolithic expansion and that the spread of agriculture was a substantially indigenous development accompanied by only a relatively minor component of contemporary Middle Eastern agriculturalists.
GENETIC EVIDENCE FOR A PLEISTOCENE POPULATION EXPLOSION
- Biology, MedicineEvolution; international journal of organic evolution
It is inferred that a major expansion of the human population occurred during the late Pleistocene, because a simple model of population history that assumes that a population grows (or shrinks) suddenly from female size N0 toFemale size N1 is studied.
Genes and languages in Europe: an analysis of mitochondrial lineages.
- Biology, MedicineGenome research
It is argued that this apparent contradiction is attributable to the fact that genetic lineages and gene frequencies reflect different time perspectives on population history, the latter being more in concordance with linguistic evolution.