Genetic heterogeneity of the hypervariable region I of Hepatitis C virus and lymphoproliferative disorders

Abstract

B-cell lymphoproliferative disorders (BCLD) have been associated with chronic hepatitis C virus (HCV) infection. The HCV glycoprotein E2 (gpE2) hypervariable region I (HVR-I) may be a potential antigenic candidate to promote B-cell proliferation. The purpose of this study was to analyze the influence of HVR-I sequence variability in the development of BCLD… (More)
DOI: 10.1038/sj.leu.2403731

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