Genetic heterogeneity of migraine with and without aura in Danes cannot be explained by mutation in mtDNA nucleotide pair 11084.

@article{Russell1997GeneticHO,
  title={Genetic heterogeneity of migraine with and without aura in Danes cannot be explained by mutation in mtDNA nucleotide pair 11084.},
  author={Michael Bj\orn Russell and Michaela Diamant and S\oren N\orby},
  journal={Acta neurologica Scandinavica},
  year={1997},
  volume={96 3},
  pages={171-3}
}
INTRODUCTION Migraine is a genetic heterogeneous disorder. The 11084 A to G base substitution is in the gene for the ND4 subunit of the respiratory complex I, and leads to a Thr to Ala amino acid replacement. This mutation had been found in 25% of Japanese migraineurs, while tension-type headache sufferers and non-migraineurs did not have it. MATERIAL AND METHODS We investigated the importance of this mutation in Danish migraineurs without aura, migraineurs with aura and non-migraineurs from… CONTINUE READING