Genetic heterogeneity of day blindness in Alaskan Malamutes.
@article{Seddon2006GeneticHO, title={Genetic heterogeneity of day blindness in Alaskan Malamutes.}, author={J. Seddon and E. Hampson and R. I. Smith and I. Hughes}, journal={Animal genetics}, year={2006}, volume={37 4}, pages={ 407-10 } }
Day blindness is a progressive and specific degeneration of cone photoreceptors in the retina of young dogs. This disorder has been associated with a breed-specific non-synonymous substitution in exon 6 of the cyclic nucleotide gated channel beta3 (CNGB3) gene in German Shorthaired Pointer dogs and a genomic deletion removing the entire gene in Alaskan Malamute dogs from the USA. To further investigate this disorder, we characterized CNGB3 in a three-generation pedigree of Alaskan Malamute dogs… CONTINUE READING
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