Genetic heterogeneity of day blindness in Alaskan Malamutes.

@article{Seddon2006GeneticHO,
  title={Genetic heterogeneity of day blindness in Alaskan Malamutes.},
  author={Jennifer M. Seddon and Ernest Hampson and Rognvald I. Smith and Ian P. Hughes},
  journal={Animal genetics},
  year={2006},
  volume={37 4},
  pages={
          407-10
        }
}
Day blindness is a progressive and specific degeneration of cone photoreceptors in the retina of young dogs. This disorder has been associated with a breed-specific non-synonymous substitution in exon 6 of the cyclic nucleotide gated channel beta3 (CNGB3) gene in German Shorthaired Pointer dogs and a genomic deletion removing the entire gene in Alaskan Malamute dogs from the USA. To further investigate this disorder, we characterized CNGB3 in a three-generation pedigree of Alaskan Malamute dogs… CONTINUE READING

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