Genetic heterogeneity of day blindness in Alaskan Malamutes.

  title={Genetic heterogeneity of day blindness in Alaskan Malamutes.},
  author={J. Seddon and E. Hampson and R. I. Smith and I. Hughes},
  journal={Animal genetics},
  volume={37 4},
  • J. Seddon, E. Hampson, +1 author I. Hughes
  • Published 2006
  • Biology, Medicine
  • Animal genetics
  • Day blindness is a progressive and specific degeneration of cone photoreceptors in the retina of young dogs. This disorder has been associated with a breed-specific non-synonymous substitution in exon 6 of the cyclic nucleotide gated channel beta3 (CNGB3) gene in German Shorthaired Pointer dogs and a genomic deletion removing the entire gene in Alaskan Malamute dogs from the USA. To further investigate this disorder, we characterized CNGB3 in a three-generation pedigree of Alaskan Malamute dogs… CONTINUE READING
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