Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43)

Abstract

Aims/hypothesis. Juvenile-onset, insulin-dependent diabetes is associated with islet cell antibodies and with specific “high-risk” HLA-DRB1 and HLA-DQB1 genotypes. Patients with Type II (non-insulin-dependent) diabetes mellitus can have islet-related antibodies, but the genotypic associations at different ages of onset have not been evaluated. Our aim was… (More)
DOI: 10.1007/s001250051202

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@article{Horton1999GeneticHO, title={Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43)}, author={Virginia A. Horton and I. M. Stratton and Gian Franco Bottazzo and Michael J. Shattock and I. S. Mackay and Paul Z. Zimmet and Sharon J. Manley and R. R. Holman and R. Turner}, journal={Diabetologia}, year={1999}, volume={42}, pages={608-616} }