Genetic heterogeneity of Alzheimer's disease: complexity and advances.

@article{Lambert2007GeneticHO,
  title={Genetic heterogeneity of Alzheimer's disease: complexity and advances.},
  author={J C Lambert and Philippe Amouyel},
  journal={Psychoneuroendocrinology},
  year={2007},
  volume={32 Suppl 1},
  pages={S62-70}
}
Most of what we know about the pathological process of Alzheimer's disease (AD) results from research on the amyloid cascade hypothesis. This hypothesis in turn is derived largely from the characterization of rare disease-causing mutations in three genes, which code for the amyloid precursor protein (APP), presenilin 1 (PS-1) and presenilin 2 (PS-2) and account for most cases of early-onset autosomal dominant familial AD. These genetic findings also suggested that better understanding of the… CONTINUE READING