Genetic heterogeneity in sporadic colorectal adenomas.

  title={Genetic heterogeneity in sporadic colorectal adenomas.},
  author={Emilia Saraga and Diana M Bautista and Gustavo Dorta and Pascal Chaubert and P. -M. Martin and Bernard Sordat and Petr Protiva and Andr{\'e} Louis Blum and Fred Bosman and Jean Benhattar},
  journal={The Journal of pathology},
  volume={181 3},
The majority of colorectal cancers develop from adenomatous polyps under the influence of factors that are still poorly understood. Tumourigenesis is generally considered a multistep process in which multiple genetic alterations occur, eventually reflected in abnormalities of the cellular DNA content. Macroscopical features such as tumour size and tumour architecture (tubular, tubulovillous, or villous) are correlated wit the chance of malignancy in the lesion. Grade of dysplasia can be… CONTINUE READING

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