Genetic heterogeneity in schizophrenia II: conditional analyses of affected schizophrenia sibling pairs provide evidence for an interaction between markers on chromosome 8p and 14q

@article{Chiu2002GeneticHI,
  title={Genetic heterogeneity in schizophrenia II: conditional analyses of affected schizophrenia sibling pairs provide evidence for an interaction between markers on chromosome 8p and 14q},
  author={Yen Feng Chiu and John A McGrath and Mary H Thornquist and Paula S. Wolyniec and Gerald Nestadt and Karen L. Swartz and Virginia K. Lasseter and Kevin YiKai Liang and Ann E Pulver},
  journal={Molecular Psychiatry},
  year={2002},
  volume={7},
  pages={658-664}
}
Information from multiple genome scans and collaborative efforts suggests that schizophrenia is a heterogeneous, complex disorder with polygenic and environmental antecedents.1 In a previous paper we demonstrated that stratification of families on the basis of co-segregating phenotypes (psychotic affective disorders (PAD) and schizophrenia spectrum personality disorders (SSPD) in first-degree relatives of schizophrenic probands increased linkage evidence in the chromosome 8p21 region (D8S1771… CONTINUE READING
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