Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.

@article{Noso2005GeneticHI,
  title={Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.},
  author={Shinsuke Noso and Hiroshi Ikegami and Tomomi Fujisawa and Yumiko Kawabata and Katsuaki Asano and Yoshihisa Hiromine and Masako Tsurumaru and Shigetaka Sugihara and Inkyu Lee and Eiji Kawasaki and Takuya Awata and Toshio Ogihara},
  journal={Diabetes},
  year={2005},
  volume={54 12},
  pages={3582-6}
}
Association studies are a potentially powerful approach to identifying susceptibility variants for common multifactorial diseases such as type 1 diabetes, but the results are not always consistently reproducible. The IDDM5 locus has recently been narrowed to an approximately 200-kb interval on chromosome 6q25 by two independent groups. These studies demonstrated that alleles at markers in the mitogen-activating protein kinase 7 interacting protein 2 (MAP3K7IP2)/SUMO4 region were associated with… CONTINUE READING

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