Genetic heterogeneity between the three components of the autism spectrum: a twin study.

@article{Ronald2006GeneticHB,
  title={Genetic heterogeneity between the three components of the autism spectrum: a twin study.},
  author={Angelica Ronald and Francesca Happ{\'e} and Patrick F. Bolton and Lee M. Butcher and Thomas S. Price and Sally J. Wheelwright and Simon Baron-Cohen and Robert Plomin},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  year={2006},
  volume={45 6},
  pages={
          691-9
        }
}
  • A. RonaldF. Happé R. Plomin
  • Published 1 June 2006
  • Psychology, Medicine
  • Journal of the American Academy of Child and Adolescent Psychiatry
OBJECTIVE This study investigated the etiology of autistic-like traits in the general population and the etiological overlap between the three aspects of the triad of impairments (social impairments, communication impairments, restricted repetitive behaviors and interests) that together define autism spectrum disorders. METHOD Parents of 3,400 8-year-old twin pairs from the Twins Early Development Study completed the Childhood Asperger Syndrome Test, a screening instrument for autism spectrum… 

Limited genetic covariance between autistic traits and intelligence: Findings from a longitudinal twin study

Investigation of the longitudinal association between autistic traits and intelligence in a general population twin sample and the etiology of this association suggest that individual differences in autistic traits are substantially genetically independent of intellectual functioning.

Relationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study

Findings from a clinical sample of twins indicate a fractionation of social/communicative and RRBI symptoms in ASD.

Autism spectrum disorders and autistic like traits: similar etiology in the extreme end and the normal variation.

An etiological similarity between ASDs and ALTs in the normal variation is demonstrated and, with results from previous studies, the data suggest that ASDsand ALTs are etiologically linked.

Phenotypic and genetic overlap between autistic traits at the extremes of the general population.

This first twin study assessing the links between extreme individual autistic-like traits found that all are highly heritable but show modest phenotypic and genetic overlap.

Genetic influences on the broad spectrum of autism: Study of proband‐ascertained twins

Autistic traits were highly heritable in twins with even broad spectrum of autism, corresponding to the results of early studies based on classical autism, and additive genetic factors were more influential in females than males.

Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample.

There are some common genetic influences operating across autistic traits and ADHD behaviours throughout normal variation and at the extreme, which is relevant for molecular genetic research, as well as for psychiatrists and psychologists, who may have assumed these two sets of behaviours are independent.

Genetic and Environmental Influences on Symptom Domains in Twins and Siblings with Autism.

The Relationship Among Genetic Heritability, Environmental Effects, and Autism Spectrum Disorders

In last 13 years, over 12,000 cases of ASD were diagnosed in the children’s development and behavior center, the authors review 37 pairs of these twins and found that the concordance rate was 80% and Genetics and special environmental effect play an important role on ASD social impairments.

Heritability of Autism Spectrum Disorder in a UK Population-Based Twin Sample.

The liability to ASD and a more broadly defined high-level autism trait phenotype in this large population-based twin sample derives primarily from additive genetic and, to a lesser extent, nonshared environmental effects.
...

References

SHOWING 1-10 OF 27 REFERENCES

Autism as a strongly genetic disorder: evidence from a British twin study

The findings indicate that autism is under a high degree of genetic control and suggest the involvement of multiple genetic loci.

Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment.

Evidence for a genetic basis of several quantitative traits that are related to autism is provided and it is suggested that they may be most promising for future gene mapping and for extending pedigrees by phenotyping additional relatives.

A case-control family history study of autism.

The findings suggest that the autism phenotype extends beyond autism as traditionally diagnosed; that aetiology involves several genes; that autism is genetically heterogeneous; and that obstetric abnormalities in autistic subjects may derive from abnormality in the foetus.

Validation of a Brief Quantitative Measure of Autistic Traits: Comparison of the Social Responsiveness Scale with the Autism Diagnostic Interview-Revised

The Social Responsiveness Scale is a valid quantitative measure of autistic traits, feasible for use in clinical settings and for large-scale research studies of autism spectrum conditions.

Heritability of social cognitive skills in children and adolescents

Social cognition appears to be under considerable genetic influence in the population and shows significant male–female differences, with younger twins showing greater genetic influence on social cognition.

Genetic structure of reciprocal social behavior.

For school-age boys in the general population, reciprocal social behavior is highly heritable, with a genetic structure similar to that reported for autism in clinical samples, and continuous measures of reciprocalsocial behavior may be useful for characterizing the broader autism phenotype.

The genetic relationship between individual differences in social and nonsocial behaviours characteristic of autism.

Considering these behaviours separately might help clarify gene-brain-behaviour pathways in future research, and it was found that some individuals had extreme scores on either social or nonsocial scales but not both.

Twins early development study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood.

A result that suggests that general impairment may be a better target for genetic research than specific language impairment independent of nonverbal cognitive problems is found, and DNA has been obtained so far for more than 4000 pairs is being used initially in molecular genetic studies of language problems and hyperactivity.

Infantile autism: a genetic study of 21 twin pairs.

  • S. FolsteinM. Rutter
  • Medicine, Psychology
    Journal of child psychology and psychiatry, and allied disciplines
  • 1977
It was concluded that brain injury in the infancy period may lead to autism on its own or in combination with a genetic predisposition, and uncertainty remains on both the mode of inheritance and exactly what is inherited.

The genetic basis of complex human behaviors.

Quantitative genetic research has built a strong case for the importance of genetic factors in many complex behavioral disorders and dimensions in the domains of psychopathology, personality, and