Genetic heterogeneity among uterine leiomyomata: insights into malignant progression.

@article{Hodge2007GeneticHA,
  title={Genetic heterogeneity among uterine leiomyomata: insights into malignant progression.},
  author={Jennelle C. Hodge and Cynthia C Morton},
  journal={Human molecular genetics},
  year={2007},
  volume={16 Spec No 1},
  pages={R7-13}
}
Uterine leiomyomata (UL), also known as fibroids, are the most common pelvic tumors in women of reproductive age and are the primary indication for hysterectomy in the USA. Many lines of evidence indicate a strong genetic component to the development of these tumors. In fact, approximately 40% of UL have non-random, tumor-specific chromosome abnormalities which have allowed classification into well-defined subgroups (deletion of portions of 7q, trisomy 12 or rearrangements of 12q15, 6p21 or… CONTINUE READING