Genetic haplotypes of Th-2 immune signalling link allergy to enhanced protection to parasitic worms.

@article{Moller2007GeneticHO,
  title={Genetic haplotypes of Th-2 immune signalling link allergy to enhanced protection to parasitic worms.},
  author={Maria Moller and Michael B. Gravenor and S E Roberts and Dejan Sun and Peisong Gao and Julian M. Hopkin},
  journal={Human molecular genetics},
  year={2007},
  volume={16 15},
  pages={1828-36}
}
Parasitic worm infection, allergy and asthma involve increased IgE production, eosinophil activity, mucus secretion and smooth muscle reactivity, effected through Th-2 immune signalling. These pathological features of allergic disorder, common in developed countries, appear to be protective features in resistance to parasitic worm infections prevalent in many developing countries. We investigated how genetic variation in the Th-2 signalling transduction molecule STAT6 relates to these clinical… CONTINUE READING