Genetic factors in non-syndromic congenital heart malformations.

Abstract

The genetic defect in most patients with non-syndromic congenital heart malformations (CHM) is unknown, although more than 40 different genes have already been implicated. Only a minority of CHM seems to be due to monogenetic mutations, and the majority occurs sporadically. The multifactorial inheritance hypothesis of common diseases suggesting that the… (More)
DOI: 10.1111/j.1399-0004.2010.01435.x

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