Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project.

@article{Cleynen2013GeneticFC,
  title={Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project.},
  author={Isabelle Cleynen and Juan Jos{\'e} Ramos Gonz{\'a}lez and Carolina Figueroa and Andre Franke and Dermot P. Mcgovern and Martin Bortl{\'i}k and Bart J A Crusius and Maurizio Vecchi and Marta Artieda and Magdalena Szczypiorska and Johannes Bethge and David Arteta and Edgar Ayala and Silvio Danese and Ruud A van Hogezand and Juli{\'a}n Pan{\'e}s and Salvador Amado Pe{\~n}a and Milan Luk{\'a}{\vs} and Derek P. Jewell and Stefan Schreiber and S{\'e}verine Vermeire and Miquel Sans},
  journal={Gut},
  year={2013},
  volume={62 11},
  pages={
          1556-65
        }
}
OBJECTIVE Through genome-wide association scans and meta-analyses thereof, over 70 genetic loci (Crohn's disease (CD) single nucleotide polymorphisms (SNPs)) are significantly associated with CD. We aimed to investigate the influence of CD-SNPs and basic patient characteristics on CD clinical course, and develop statistical models to predict CD clinical course. DESIGN This retrospective study included 1528 patients with CD with more than 10 years of follow-up from eight European referral… CONTINUE READING

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