Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy
@article{Snchez2010GeneticFA, title={Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy}, author={M. B. S{\'a}nchez and J. Herranz and C. Leno and R. Arteaga and A. Oterino and E. Valdiz{\'a}n and J. Nicol{\'a}s and J. Ad{\'i}n and J. Armijo}, journal={Seizure}, year={2010}, volume={19}, pages={93-101} }
Epilepsy drug-resistance may depend on the metabolism of antiepileptic drugs (AEDs), transport to the epileptic focus and/or target sensitivity. Furthermore, drug response depends on multiple characteristics of the patient, the epilepsy, and the antiepileptic drugs used. We have investigated the association between polymorphisms related to antiepileptic drug metabolism (CYP2C9, CYP2C19, and UGT), transport (ABCB1), and targets (SCN1A) both in a crude analysis and after adjusting by clinical… Expand
Paper Mentions
Observational Clinical Trial
This study is to identify the clinical criteria of drug resistant epilepsy and to explore
whether SCN1A c.3184 A/G (rs2298771) and ccl2(rs1024611) polymorphisms could serve as genetic… Expand
Conditions | Epilepsy, Drug Resistant |
---|---|
Intervention | Genetic |
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