Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy

@article{Snchez2010GeneticFA,
  title={Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy},
  author={M. Blanca S{\'a}nchez and Jos{\'e} Luis Herranz and Carlos Leno and Rosa Arteaga and Agust{\'i}n Oterino and Elsa Mar{\'i}a Valdiz{\'a}n and Josep Mar{\'i}a Nicol{\'a}s and Javier Ad{\'i}n and Juan A. Armijo},
  journal={Seizure},
  year={2010},
  volume={19},
  pages={93-101}
}

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TLDR
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References

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TLDR
Patients with drug-resistant epilepsy were more likely to have the CC genotype at ABCB1 3435 than the TT genotype, implying that the polymorphism may not itself be causal but rather may be linked with the causal variant.
Various Pharmacogenetic Aspects of Antiepileptic Drug Therapy
TLDR
Polymorphisms of drug targets may represent another genetic facet in epilepsy: a recent study demonstrated for the first time a polymorphism of a drug target associated in clinical practice with differing response to two classic AEDs.
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TLDR
It is demonstrated that ABCB1 polymorphisms may influence the AED responsiveness without significant changes in the plasma concentrations of CBZ, the inverse of previous results in European epileptics, thus the influence of ABCB 1 polymorphisms on the Aed responsiveness and/or the P-glycoprotein activity may vary among races.
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TLDR
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TLDR
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