Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy

@article{Snchez2010GeneticFA,
  title={Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy},
  author={Mar{\'i}a Blanca S{\'a}nchez and Jos{\'e} Luis Herranz and Carlos Leno and Rosa Mar{\'i}a Arteaga and Agust{\'i}n Oterino and Elsa Mar{\'i}a Valdiz{\'a}n and J. M. Nicolas and Javier Ad{\'i}n and Juan Antonio Armijo},
  journal={Seizure},
  year={2010},
  volume={19},
  pages={93-101}
}
Epilepsy drug-resistance may depend on the metabolism of antiepileptic drugs (AEDs), transport to the epileptic focus and/or target sensitivity. Furthermore, drug response depends on multiple characteristics of the patient, the epilepsy, and the antiepileptic drugs used. We have investigated the association between polymorphisms related to antiepileptic drug metabolism (CYP2C9, CYP2C19, and UGT), transport (ABCB1), and targets (SCN1A) both in a crude analysis and after adjusting by clinical… CONTINUE READING

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