Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy

@article{Snchez2010GeneticFA,
  title={Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy},
  author={M. B. S{\'a}nchez and J. Herranz and C. Leno and R. Arteaga and A. Oterino and E. Valdiz{\'a}n and J. Nicol{\'a}s and J. Ad{\'i}n and J. Armijo},
  journal={Seizure},
  year={2010},
  volume={19},
  pages={93-101}
}
Epilepsy drug-resistance may depend on the metabolism of antiepileptic drugs (AEDs), transport to the epileptic focus and/or target sensitivity. Furthermore, drug response depends on multiple characteristics of the patient, the epilepsy, and the antiepileptic drugs used. We have investigated the association between polymorphisms related to antiepileptic drug metabolism (CYP2C9, CYP2C19, and UGT), transport (ABCB1), and targets (SCN1A) both in a crude analysis and after adjusting by clinical… Expand
64 Citations

Paper Mentions

Observational Clinical Trial
This study is to identify the clinical criteria of drug resistant epilepsy and to explore whether SCN1A c.3184 A/G (rs2298771) and ccl2(rs1024611) polymorphisms could serve as genetic… Expand
ConditionsEpilepsy, Drug Resistant
InterventionGenetic
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  • 5
  • Highly Influenced
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  • Highly Influenced
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  • 13
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References

SHOWING 1-10 OF 67 REFERENCES
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.
  • 641
  • Highly Influential
  • PDF
ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients.
  • 145
  • Highly Influential
The clinical impact of pharmacogenetics on the treatment of epilepsy
  • 230
  • Highly Influential
Refractory Epilepsy: Clinical Overview
  • 335
...
1
2
3
4
5
...