• Biology, Medicine
  • Published in Genetics 1999

Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast.

@article{Tran1999GeneticFA,
  title={Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast.},
  author={Huong Thi Thu Tran and Natasha P. Degtyareva and Dmitry A Gordenin and Michael A. Resnick},
  journal={Genetics},
  year={1999},
  volume={152 1},
  pages={
          47-59
        }
}
Base selectivity, proofreading, and postreplication mismatch repair are important for replication fidelity. Because proofreading plays an important role in error correction, we have investigated factors that influence its impact in the yeast Saccharomyces cerevisiae. We have utilized a sensitive mutation detection system based on homonucleotide runs of 4 to 14 bases to examine the impact of DNA polymerase delta proofreading on mutation avoidance. The contribution of DNA polymerase delta… CONTINUE READING

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VIEW 2 EXCERPTS
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References

Publications referenced by this paper.
SHOWING 1-10 OF 11 REFERENCES

Replication slippage between distantboth DNA polymerase d and ε participate in correcting errors short repeats in Saccharomyces cerevisiae depends on the directionof DNA replication in S . cerevisiae

H. T. Tran, D. Gordenin, M. Resnick
  • Mol . Gen . Genet .
  • 1995
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

DNA polymerase Pavlov , 1996 Base analog N 6 - hydroxylaminopurine mutagene - delta is required for human mismatch repair in vitro

G. F. Fink, J. B. Hicks
  • Mutat . Res .
  • 1997

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1994
VIEW 1 EXCERPT

Characterization of inser - nuclease Exo 1 have major roles in postreplication mutation avoid - tion mutations in the Saccharomyces cerevisiae MSH 1 and MSH 2 ance in Saccharomyces cerevisiae

E. F. Fritsch, J. Maniatis
  • Mol . Cell . Biol .
  • 1992

Mutagenesis by transient misalign - Schaaper , R . M . , 1993 Base selection , proofreading , and mismatchment

R. M. Schaaper
  • J . Biol . Chem .
  • 1988
VIEW 2 EXCERPTS

Methods in Yeast caused by an amino acid change in the alpha subunit of DNA Genetics . Cold Spring Harbor Laboratory Press , Cold Spring Har - polymerase III of Escherichia coli

C. S. McHenry, W. Crow, P. Greenwell
  • J . Biol . Chem .
  • 1986