Genetic expression of extracellular matrix proteins correlates with histologic changes during fracture repair.

@article{Jingushi1992GeneticEO,
  title={Genetic expression of extracellular matrix proteins correlates with histologic changes during fracture repair.},
  author={Seiya Jingushi and Michael E Joyce and Mark E. Bolander},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1992},
  volume={7 9},
  pages={1045-55}
}
We characterized gene expression in the reparative callus that formed after fracture of the rat femur. The callus was divided into regions of bone formation (hard callus) and cartilage formation (soft callus), and gene expression was examined separately in each region. Expression of extracellular matrix protein genes varied with the progression of repair and differed between hard and soft calluses. Messenger ribonucleic acids (mRNAs) for osteonectin, alkaline phosphatase, and type I procollagen… CONTINUE READING
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