Genetic evolution of gp41 reveals a highly exclusive relationship between codons 36, 38 and 43 in gp41 under long-term enfuvirtide-containing salvage regimen.

@article{Cabrera2006GeneticEO,
  title={Genetic evolution of gp41 reveals a highly exclusive relationship between codons 36, 38 and 43 in gp41 under long-term enfuvirtide-containing salvage regimen.},
  author={Cecilia Cabrera and S{\'i}lvia Marfil and Elisabet Kadar Garcia and Javier Martinez-Picado and Anna Bonjoch and Margarita Bofill and Santiago Moreno and Esteban Ribera and Pere Domingo and Bonaventura Clotet and Lidia Ruiz},
  journal={AIDS},
  year={2006},
  volume={20 16},
  pages={2075-80}
}
OBJECTIVE To analyse the genetic changes in the gp41 protein in HIV-infected patients with detectable plasma viraemia receiving a long-term salvage enfuvirtide regimen. METHODS We studied 13 heavily antiretroviral-experienced patients receiving a salvage regimen containing enfuvirtide. Substitutions in gp41 were analysed by population-based sequencing at baseline and longitudinally after the initiation of enfuvirtide treatment. To investigate sequence evolution we also analysed multiple gp41… CONTINUE READING