Genetic evidence that the uvsE gene product of Deinococcus radiodurans R1 is a UV damage endonuclease.

@article{Earl2002GeneticET,
  title={Genetic evidence that the uvsE gene product of Deinococcus radiodurans R1 is a UV damage endonuclease.},
  author={Ashlee M. Earl and Sara K. Rankin and Kwang-Pyo Kim and Oleana N Lamendola and John R. Battista},
  journal={Journal of bacteriology},
  year={2002},
  volume={184 4},
  pages={
          1003-9
        }
}
  • Ashlee M. Earl, Sara K. Rankin, +2 authors John R. Battista
  • Published in Journal of bacteriology 2002
  • Biology, Medicine
  • An in vitro transposition system, developed to facilitate gene disruption in Deinococcus radiodurans R1, has been used to inactivate the gene designated dr1819 in uvrA-1(+) and uvrA-1 backgrounds. dr1819 encodes a protein with homology to a UV DNA damage endonuclease expressed by Schizosaccharomyces pombe. Interruption of dr1819 greatly sensitizes the uvrA-1 strain but not the uvrA-1(+) strain to UV light, indicating that the dr1819 gene product is a component in a DNA repair pathway that can… CONTINUE READING

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