Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

  title={Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes},
  author={John R. B. Perry and M. N. Weedon and Claudia Langenberg and Anne U. Jackson and Valeriya Lyssenko and Thomas Hempel Spars\o and Gudmar Thorleifsson and Harald Grallert and Luigi Ferrucci and Marcello Maggio and Giuseppe Paolisso and Mark Walker and Colin N A Palmer and Felicity Payne and Elizabeth Young and Christian Herder and Narisu Narisu and Mario A. Morken and Lori L. Bonnycastle and K Owen and Beverley M Shields and B. J. Knight and Amanda Bennett and Christopher James Groves and Aimo O Ruokonen and Marjo Riitta Jarvelin and Ewan Pearson and Laura Pascoe and Ele Ferrannini and Stefan R. Bornstein and Heather M Stringham and Laura J. Scott and Johanna Kuusisto and Peter Nilsson and Malin Neptin and Anette Prior Gjesing and Charlotta H Pisinger and T Lauritzen and Annelli Sandbaek and Mike Sampson and Ele Zeggini MAGIC and Cecilia M. Lindgren and Valgerdur Steinthorsdottir and Unnur Thorsteinsdottir and Torben Hansen and Peter D. Schwarz and Thomas Illig and Markku Laakso and K{\'a}ri Stef{\'a}nsson and Andrew D. Morris and Leif Groop and Oluf Pedersen and Michael Boehnke and In{\^e}s Barroso and Nicholas J Wareham and Andrew T Hattersley and Mark I. McCarthy and Timothy M. Frayling},
  booktitle={Human molecular genetics},
Epidemiological studies consistently show that circulating sex hormone binding globulin (SHBG) levels are lower in type 2 diabetes patients than non-diabetic individuals, but the causal nature of this association is controversial. Genetic studies can help dissect causal directions of epidemiological associations because genotypes are much less likely to be confounded, biased or influenced by disease processes. Using this Mendelian randomization principle, we selected a common single nucleotide… CONTINUE READING