Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function

@article{Ibrahim2001GeneticET,
  title={Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function},
  author={Hisham Radwan Ibrahim and Takao Matsuzaki and Takayoshi Aoki},
  journal={FEBS Letters},
  year={2001},
  volume={506}
}
The Peptidoglycan-Degrading Property of Lysozyme Is Not Required for Bactericidal Activity In Vivo1
TLDR
Results indicate that the muramidase activity of lysozyme is not required for bacterial killing in vitro or in vivo.
Molecular Basis of Resistance to Muramidase and Cationic Antimicrobial Peptide Activity of Lysozyme in Staphylococci
TLDR
It is shown that a Staphylococcus aureus double mutant defective in O-acetyltransferase A (OatA), and the glycopeptide resistance-associated two-component system, GraRS, is much more sensitive to lysozyme than S. aUREus with the oatA mutation alone.
Antimicrobial Properties of Lysozyme in Relation to Foodborne Vegetative Bacteria
TLDR
Insight in the underlying causes of bacterial resistance or sensitivity to lysozyme is provided to improve understanding of the role of this ubiquitous enzyme in antibacterial defense strategies in nature and provides a basis for the development and improvement of applications of this enzyme as an antibacterial agent.
The bactericidal action on Escherichia coli of ZF‐RNase‐3 is triggered by the suicidal action of the bacterium OmpT protease
TLDR
The most remarkable result obtained in the present study is the finding that the microbicidal action of ZF‐RNase‐3 can be achieved only with the suicidal cooperation of the bacterium itself.
Editorial: O-specific polysaccharide confers lysozyme resistance to extraintestinal pathogenic Escherichia coli
TLDR
The authors demonstrate how LPS structure influences its inhibitory activity against enzymatic and bactericidal activity of LZ against Gram-positive and Gram-negative bacteria.
The antimicrobial spectrum of lysozyme broadened by reductive modification
TLDR
The integrated results suggest that the Na2SO3-reduced lysozyme can be used as a novel safe potential bactericidal additive for food-processing industry.
Genetically enhanced lysozyme evades a pathogen derived inhibitory protein.
TLDR
E engineering hLYZ for broad-spectrum evasion of proteinaceous inhibitors will require consideration of the complex and varied determinants that underlie molecular recognition by these emerging virulence factors.
Dual Activity of a Viral Lysozyme with High Efficiency for Growth Inhibition of Erwinia amylovora.
ABSTRACT The lysozyme from Erwinia amylovora phage PhiEa1h was investigated for its ability to inhibit growth of bacteria and compared with the lysozyme from Escherichia coli phage T4. The assays to
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References

SHOWING 1-10 OF 34 REFERENCES
On the novel catalytically-independent antimicrobial function of hen egg-white lysozyme: a conformation-dependent activity.
TLDR
It is worth emphasizing that the naturally-occurring conformational transition of lysozyme at physiological temperatures can be a biologically relevant event to switch its antimicrobial specificity to include the food-borne pathogens and heralding fascinating opportunities for application in formulated food systems.
A Structural Phase of Heat-Denatured Lysozyme with Novel Antimicrobial Action
TLDR
Interestingly, lysozyme heated for 20 min, devoid of enzyme activity (HDLz), killed Escherichia coli K12 in a dose-dependent manner, while its bactericidal activity to Staphylococcus aureus was almost similar to that of the nat...
Partially Unfolded Lysozyme at Neutral pH Agglutinates and Kills Gram-Negative and Gram-Positive Bacteria through Membrane Damage Mechanism
TLDR
The results introduce an interesting finding that partial unfolding of lysozyme with the proper acquisition of the hydrophobic pocket to the surface can switch its antimicrobial activity to include Gram-negative bacteria without a detrimental effect on the inherent bactericidal effect against Gram-positive ones.
Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis: inhibition by chitin oligosaccharides
TLDR
Results suggested that the essential bactericidal property of ly sozyme was its extreme cationic nature and that some bacterial endogenous activities, inhibitable by chitotriose and chitobiose, were essential for expression of the bactericidal activity of either native or muramidase-inactive lysozyme or of the cationsic homopolypeptides.
Lysis and aberrant morphology of Bacillus subtilis cells caused by surfactants and their relation to autolysin activity.
TLDR
Results obtained with inhibitors and a mutant that had defective autolytic enzymes suggested that cell lysis resulted from the deregulation of autolysin activity, suggesting that surfactants interfere with the role of Autolysins in normal construction of the cell envelope.
Crystal structure of the mutant D52S hen egg white lysozyme with an oligosaccharide product.
The crystal structure of a mutant hen egg white lysozyme, in which the key catalytic residue aspartic acid 52 has been changed to a serine residue (D52S HEWL), has been determined and refined to a
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