Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors.

@article{Egawa2005GeneticES,
  title={Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors.},
  author={Takeshi Egawa and G{\'e}rard Eberl and Ichiro Taniuchi and Kamel Benlagha and Fr{\'e}d{\'e}ric Geissmann and Lothar Hennighausen and Albert Bendelac and Dan R. Littman},
  journal={Immunity},
  year={2005},
  volume={22 6},
  pages={705-16}
}
Invariant Valpha14i NKT (iNKT) cells are a specialized subset of T lymphocytes with regulatory functions. They coexpress TCRalphabeta and natural killer cell markers. They differentiate through interaction of their Valpha14-Jalpha18 invariant TCRalpha chains with CD1d expressed on double-positive (DP) thymocytes. Although their development has been shown to be thymus dependent, their developmental pathway has not been definitively established. By using genetic analyses, we show here that all… CONTINUE READING

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