Genetic evidence of the regulatory role of parathyroid hormone-related protein in articular chondrocyte maintenance in an experimental mouse model.

@article{Macica2011GeneticEO,
  title={Genetic evidence of the regulatory role of parathyroid hormone-related protein in articular chondrocyte maintenance in an experimental mouse model.},
  author={Carolyn M. Macica and Guoying Liang and Ali Beigi Nasiri and Arthur E. Broadus},
  journal={Arthritis and rheumatism},
  year={2011},
  volume={63 11},
  pages={3333-43}
}
OBJECTIVE Parathyroid hormone-related protein (PTHrP) regulates the rate of differentiation of growth chondrocytes and is also expressed in articular chondrocytes. This study tested the hypothesis that PTHrP might have a regulatory role in articular chondrocyte maintenance. METHODS Control sequences of growth differentiation factor 5 were used to delete PTHrP from articular chondrocytes in the mid-region of mouse articular cartilage. Mice with conditional deletion of PTHrP (knockout [KO]) and… CONTINUE READING

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