Genetic evidence of an essential role for cytomegalovirus small capsid protein in viral growth.

@article{Borst2001GeneticEO,
  title={Genetic evidence of an essential role for cytomegalovirus small capsid protein in viral growth.},
  author={Eva Maria Borst and Sophie Mathys and Maximilian E.H. Wagner and Walter Muranyi and Martin Messerle},
  journal={Journal of virology},
  year={2001},
  volume={75 3},
  pages={
          1450-8
        }
}
Many steps in the replication cycle of cytomegalovirus (CMV), like cell entry, capsid assembly, and egress of newly synthesized virions, have not been completely analyzed yet. In order to facilitate these studies, we decided to construct a recombinant CMV that incorporates the green fluorescent protein (GFP) into the nucleocapsid. A comparable herpes simplex virus type 1 (HSV-1) mutant has recently been generated by fusion of the GFP open reading frame (ORF) with the HSV-1 ORF encoding small… CONTINUE READING

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