Genetic evidence for transmembrane acetylation by lysosomes.

  title={Genetic evidence for transmembrane acetylation by lysosomes.},
  author={Karen J Bame and Leonard H Rome},
  volume={233 4768},
Acetyl-CoA:alpha-glucosaminide N-acetyltransferase is a lysosomal-membrane enzyme deficient in a genetic disorder, Sanfilippo disease type C. The enzyme catalyzes the transfer of an acetyl group from cytoplasmic acetyl-coenzyme A (acetyl-CoA) to terminal alpha-glucosamine residues of heparan sulfate within the organelle. Previous kinetic experiments indicated that the enzyme carries out a transmembrane acetylation via a ping-pong mechanism; the reaction can therefore be dissected into two half… CONTINUE READING

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