Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice.

@article{Tong2001GeneticEF,
  title={Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice.},
  author={W Tong and Jeffrey W. Pollard},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 4},
  pages={1319-28}
}
The cell cycle of cultured cells appears to be regulated by opposing actions of the cyclins together with their partners, the cyclin-dependent kinases (Cdk), and their inhibitors (Cki). Consistent with this situation null mutations in the genes for cyclin D1 and Cki p27(Kip1) in mice give opposite phenotypes of dwarfism and gigantism. To test their genetic… CONTINUE READING