Genetic evidence for the correlation of deep dorsal horn Fos protein immunoreactivity with tonic formalin pain behavior.

@article{Bon2002GeneticEF,
  title={Genetic evidence for the correlation of deep dorsal horn Fos protein immunoreactivity with tonic formalin pain behavior.},
  author={Karine Bon and Sonya G. Wilson and Jeffrey S Mogil and William J Roberts},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2002},
  volume={3 3},
  pages={181-9}
}
The formalin test is commonly used as a model of persistent pain. Besides producing pain behavior, hind paw formalin injection induces the expression of the immediate-early gene, c-fos. A current controversy is whether noxious stimulus-induced Fos protein immunoreactivity can be considered a proxy (biomarker) of nociception in the spinal cord. We investigated this issue by exploiting our recent demonstration of genotype-dependent behavioral differences in response to formalin injection among… CONTINUE READING

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