Genetic evidence for high-altitude adaptation in Tibet.

@article{Simonson2010GeneticEF,
  title={Genetic evidence for high-altitude adaptation in Tibet.},
  author={Tatum S. Simonson and Yingzhong Yang and Chad D. Huff and Haixia Yun and Ga Qin and David J. Witherspoon and Zhenzhong Bai and Felipe Ramos Lorenzo and Jinchuan Xing and Lynn B. Jorde and Josef T Prchal and Rili Ge},
  journal={Science},
  year={2010},
  volume={329 5987},
  pages={72-5}
}
Tibetans have lived at very high altitudes for thousands of years, and they have a distinctive suite of physiological traits that enable them to tolerate environmental hypoxia. These phenotypes are clearly the result of adaptation to this environment, but their genetic basis remains unknown. We report genome-wide scans that reveal positive selection in several regions that contain genes whose products are likely involved in high-altitude adaptation. Positively selected haplotypes of EGLN1 and… CONTINUE READING
Highly Influential
This paper has highly influenced 36 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 11 times. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 266 extracted citations

Different Erythrocyte MicroRNA Profiles in Low- and High-Altitude Individuals

Front. Physiol. • 2018
View 8 Excerpts
Highly Influenced

Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations

Molecular biology and evolution • 2016
View 17 Excerpts
Highly Influenced

Systems Biology Approach to Study the High Altitude Adaptation in Tibetans

Bi De, Xiao Huajun, +3 authors Liu Xiaopeng
2013
View 12 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 12 references

BMC Genomics

S C Huff, H Harpending, A Rogers
BMC Genomics • 2010

Genome Research

D H Alexander, J Novembre, K Lange
Genome Research • 2009

Proceedings of the National Academy of Sciences The American Journal of Human Genetics

M Zhao
Proceedings of the National Academy of Sciences The American Journal of Human Genetics • 2009

Cardiovascular Research

S H Cai, D Liu, J G N Garcia
Cardiovascular Research • 2008

Nature

S P C Sabeti
Nature • 2007

Nucl. Acids Res

H Mi, N Guo, A Kejariwal, P D Thomas
Nucl. Acids Res • 2007

PLoS Biology

S B F Voight, S Kudaravalli, X Wen, J K Pritchard
PLoS Biology • 2006

Science

S S E J Williams
Science • 2004

Genes & Development

S W Zundel
Genes & Development • 2000

Similar Papers

Loading similar papers…