Genetic evidence for a temperature-sensitive lesion in the adenovirus 7 region of the PARA genome.

Abstract

It has previously been shown that the helper adenovirus (Ad) present in the defective Ad 7-SV40 hybrid population is temperature-sensitive (ts) for replication in human cells. This study has shown that the replication of the defective hybrid virus (PARA) in green monkey kidney cells is also restricted at 40.5 percent. Complementation tests between the… (More)

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