Genetic evidence for a connection between Rous sarcoma virus gag nuclear trafficking and genomic RNA packaging.

@article{GarbittHirst2009GeneticEF,
  title={Genetic evidence for a connection between Rous sarcoma virus gag nuclear trafficking and genomic RNA packaging.},
  author={Rachel Garbitt-Hirst and Scott P. Kenney and Leslie J. Parent},
  journal={Journal of virology},
  year={2009},
  volume={83 13},
  pages={6790-7}
}
The packaging of retroviral genomic RNA (gRNA) requires cis-acting elements within the RNA and trans-acting elements within the Gag polyprotein. The packaging signal psi, at the 5' end of the viral gRNA, binds to Gag through interactions with basic residues and Cys-His box RNA-binding motifs in the nucleocapsid. Although specific interactions between Gag and gRNA have been demonstrated previously, where and when they occur is not well understood. We discovered that the Rous sarcoma virus (RSV… CONTINUE READING
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