Genetic evidence for Lyn as a negative regulator of IL-4 signaling.

@article{Janas1999GeneticEF,
  title={Genetic evidence for Lyn as a negative regulator of IL-4 signaling.},
  author={Michelle L. Janas and Phil D. Hodgkin and Margaret L. Hibbs and David M Tarlinton},
  journal={Journal of immunology},
  year={1999},
  volume={163 8},
  pages={4192-8}
}
IL-4 has multiple effects on B lymphocytes, many of which are concentration dependent. This is particularly so for Ig isotype switching, where different thresholds of IL-4 stimulation are needed to induce switching from IgM to either IgG1 or IgE. In this report we describe a critical role for the tyrosine kinase Lyn in setting IL-4 signaling thresholds in mouse B lymphocytes. Upon CD40 ligand stimulation of lyn-/- B cells, 10-fold less IL-4 was required to induce switching from IgM to IgG1 and… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…