Genetic evaluation of suspected cases of transient HIV-1 infection of infants.

@article{Frenkel1998GeneticEO,
  title={Genetic evaluation of suspected cases of transient HIV-1 infection of infants.},
  author={L. Frenkel and J. Mullins and G. Learn and L. Manns-Arcuino and B. Herring and M. Kalish and R. Steketee and D. Thea and J. Nichols and S. Liu and A. Harmache and X. He and D. Muthui and A. Madan and L. Hood and A. Haase and M. Zupancic and K. Staskus and Steven Wolinsky and P. Krogstad and J. Zhao and I. Chen and R. Koup and D. Ho and B. Korber and R. Apple and R. Coombs and S. Pahwa and N. Roberts},
  journal={Science},
  year={1998},
  volume={280 5366},
  pages={
          1073-7
        }
}
Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly… Expand
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References

SHOWING 1-10 OF 15 REFERENCES
Clearance of HIV infection in a perinatally infected infant.
TLDR
The child is five years of age at this writing, is HIV-seronegative, and remains well, with normal growth and development and no laboratory or clinical evidence of HIV-1 infection. Expand
Mother-to-infant transmission of human immunodeficiency virus type 1 involving five envelope sequence subtypes
TLDR
No consistent correlation was found to support the hypothesis that infant viruses should match blood-derived maternal virus genotypes found early in pregnancy if infants were found to be infected at birth or, conversely, that infant virus populations should matchBlood- derived maternal virus Genotypes found at delivery if infants are found to have been infected only some time later. Expand
Repeatedly positive human immunodeficiency virus type 1 DNA polymerase chain reaction in human immunodeficiency virus-exposed seroreverting infants.
TLDR
The transiently positive DNA PCR in HIV-exposed infants may indicate either that HIV infection was eliminated by a strong host immune response or that infection was caused by an attenuated/defective strain of virus. Expand
Molecular investigation of human immunodeficiency virus (HIV) infection in a patient of an HIV-infected surgeon.
TLDR
Recall of patients who had been treated by a human immunodeficiency virus (HIV)-infected surgeon uncovered 1 previously unknown HIV-seropositive person and it was concluded that none of the recalled patients were infected by the surgeon. Expand
Detection of virus in vertically exposed HIV-antibody-negative children
TLDR
The detection of virus or viral DNA in "uninfected" children born to HIV-infected mothers was rare and was not associated with clinical disease or immunological abnormalities. Expand
Maternal HIV-1 viral load and vertical transmission of infection: The Ariel Project for the prevention of HIV transmission from mother to infant
TLDR
It is suggested that a high maternal viral load is insufficient to fully explain vertical transmission of HIV-1, and additional studies are needed to examine the post-partum increase in viremia. Expand
Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to HIV-1-infected mothers.
Human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) activity against different viral antigens, including env, gag/pol, and nef, was detected in peripheral bloodExpand
Early detection of perinatal human immunodeficiency virus (HIV) type 1 infection using HIV RNA amplification and detection. New York City Perinatal HIV Transmission Collaborative Study.
TLDR
Results suggest that plasma HIV RNA was detectable earlier and more reliably than HIV DNA in perinatal infection. Expand
PCR analysis of HIV-seronegative, heterosexual partners of HIV-infected individuals.
  • P. Palumbo, J. Skurnick, D. Lewis, M. Eisenberg
  • Biology, Medicine
  • Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
  • 1995
TLDR
The results confirm previous studies that document a negligible incidence of occult HIV infection as delineated by PCR in antibody negative heterosexual partners of HIV-infected individuals. Expand
Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection
TLDR
A CKR-5 allele present in the human population appears to protect homozygous individuals from sexual transmission of HIV-1 and is suggested to provide a means of preventing or slowing disease progression. Expand
...
1
2
...