Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.

@article{Grabe2012GeneticEB,
  title={Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.},
  author={Hans J{\"o}rgen Grabe and Christian Schwahn and Jessie Mahler and Katja Appel and Andrea Schulz and Carsten Spitzer and Kristin Fenske and Sven Barnow and Harald J{\"u}rgen Freyberger and Alexander Teumer and Astrid Petersmann and Reiner Biffar and Dieter Rosskopf and U. John and Henry V{\"o}lzke},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2012},
  volume={36 2},
  pages={264-70}
}
BACKGROUND Based on biological interactions between the serotonergic system and the brain-derived neurotrophic factor (BDNF), BDNF is a plausible candidate for a gene-gene-environment interaction moderating the interaction between the s/l- promoter polymorphism of the serotonin transporter (5-HTTLPR) and childhood abuse. We tested the hypothesis of a three-way interaction with respect to depressive symptoms. METHODS 2035 Caucasian subjects from the Study of Health in Pomerania (German general… CONTINUE READING