Genetic epidemiology of familial amyloidotic polyneuropathy (FAP)-type I in Póvoa do Varzim and Vila do Conde (north of Portugal).

@article{Sousa1995GeneticEO,
  title={Genetic epidemiology of familial amyloidotic polyneuropathy (FAP)-type I in P{\'o}voa do Varzim and Vila do Conde (north of Portugal).},
  author={Alda Sousa and Teresa Coelho and Jos{\'e} Wellington Barros and J Sequeiros},
  journal={American journal of medical genetics},
  year={1995},
  volume={60 6},
  pages={512-21}
}
Familial amyloidotic polyneuropathy (FAP-type I) was first described in Portugal by Andrade in 1952, a time when 54 among 64 patients (belonging to 25 families) originated from Póvoa do Varzim or its surrounding districts. Since then, a total of 1,233 patients, belonging to 489 pedigrees (so far unrelated), have been diagnosed at Centro de Estudos de Paramiloidose, Porto, Portugal. Although age-of-onset showed a wide range (17 to 78 years), 87% of these 1,233 patients developed symptoms before… CONTINUE READING
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