Genetic epidemiology of bipolar disorder

  title={Genetic epidemiology of bipolar disorder},
  author={Kathleen Ries Merikangas and Kelly J. Yu},
  journal={Clinical Neuroscience Research},
Objective: To present a summary of recent studies of the familial aggregation and the role of genetic factors in the etiology of mood disorders. Methods: Review of empirical evidence from studies of familial aggregation and association and linkage for mood disorder. Results: The weighted average risk ratio for bipolar disorder among relatives of bipolar probands is 9.2, whereas major depressive disorder (MDD) among relatives of bipolar probands compared to those of controls is 1.9. In contrast… CONTINUE READING