Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis

  title={Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis},
  author={Z. Zou and Zhi-rui Zhou and C. Che and Chang-yun Liu and Raoli He and H. Huang},
  journal={Journal of Neurology, Neurosurgery & Psychiatry},
  pages={540 - 549}
  • Z. Zou, Zhi-rui Zhou, +3 authors H. Huang
  • Published 2017
  • Biology, Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
  • Background Genetic studies have shown that C9orf72, SOD1, TARDBP and FUS are the most common mutated genes in amyotrophic lateral sclerosis (ALS). Here, we performed a meta-analysis to determine the mutation frequencies of these major ALS-related genes in patients with ALS. Methods We performed an extensive literature research to identify all original articles reporting frequencies of C9orf72, SOD1, TARDBP and FUS mutations in ALS. The mutation frequency and effect size of each study were… CONTINUE READING
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