Genetic epidemiology: Giant cell arteritis and polymyalgia rheumatica

@article{GonzlezGay2001GeneticEG,
  title={Genetic epidemiology: Giant cell arteritis and polymyalgia rheumatica},
  author={Miguel A Gonz{\'a}lez-Gay},
  journal={Arthritis Research},
  year={2001},
  volume={3},
  pages={154 - 157}
}
Giant cell arteritis (GCA) (temporal arteritis) and polymyalgia rheumatica (PMR) are common, frequently related conditions in people generally over 50 years of age. Most studies have shown an association of GCA with HLA-DRB1 *04 alleles. As regards isolated PMR, however, the HLA class II genetic susceptibility varies from one population to another. Besides associations with HLA, tumor necrosis factor appears to influence susceptibility to both conditions. Genetic polymorphisms have also been… CONTINUE READING

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