Genetic epidemiology, endophenotypes, and eating disorder classification.

@article{Bulik2007GeneticEE,
  title={Genetic epidemiology, endophenotypes, and eating disorder classification.},
  author={Cynthia M. Bulik and Johannes Hebebrand and Anna Keski-Rahkonen and Kelly L. Klump and Ted Reichborn-Kjennerud and Suzanne E Mazzeo and Tracey D. Wade},
  journal={The International journal of eating disorders},
  year={2007},
  volume={40 Suppl},
  pages={
          S52-60
        }
}
OBJECTIVE To explore how genetic epidemiology has informed the identification of endophenotypes and how endophenotypes may inform future classification of eating disorders. METHOD Literature review and synthesis. RESULTS Although a number of endo- and subphenotypes have been suggested for eating disorders, few reach the rigorous definitions developed for candidate endophenotypes. CONCLUSION Further study of endophenotypes and subphenotypes for eating disorders may assist with developing a… 
Biomarkers and Endophenotypes in Eating Disorders
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Interspecies genetics of eating disorder traits
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  • 2009
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Genetics and Epigenetics of Eating Disorders.
TLDR
The foremost goal of current genetic research on eating disorders is to identify all loci and pathways that confer risk or protection and to use identified loci to inform prevention and treatment approaches.
Genetics and Epigenetics of Eating Disorders.
TLDR
The diagnostic criteria, clinical features, prevalence, and prognosis of AN, BN, and BED are reviewed, followed by a review of family, twin, and adoption studies and the history of genetic studies of EDs is reviewed.
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All seven variables were significantly associated with clinically significant importance of shape and weight, while thin-ideal internalization, ineffectiveness, body dissatisfaction and sensitivity to punishment were found at significantly elevated levels in non-affected twins, when controlling for sister's temperament score.
Animal models of eating disorder traits.
  • M. Kas, R. Adan
  • Medicine, Psychology
    Current topics in behavioral neurosciences
  • 2011
TLDR
Novel mouse genetic and phenotyping tools offer a way to study neurobehavioral traits under controlled environmental and genetic background conditions and will be relevant to develop new therapies for patients within the heterogeneous eating disorder populations.
[Pathogenesis of anorexia nervosa. Neurobiological risk factors and possible endophenotypes].
TLDR
This review focuses on the heterogenity of the disease with emphasis on special diagnostic implications in case of childhood onset and gives a summary of the most investigated neurobiologic and neurocognitive factors which could be the fundaments of a biological vulnerablilty.
Eating disorders: the current status of molecular genetic research
TLDR
Genome-wide association studies are under way and will presumably help to identify genes and pathways involved in these eating disorders, and the elucidation of the molecular mechanisms underlying eating disorders might improve therapeutic approaches.
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