Genetic enhancement of stem cell engraftment, survival, and efficacy.

  title={Genetic enhancement of stem cell engraftment, survival, and efficacy.},
  author={Marc S. Penn and Abeel A. Mangi},
  journal={Circulation research},
  volume={102 12},
Cell-based therapies for the prevention and treatment of cardiac dysfunction offer the potential to significantly modulate cardiac function and improve outcomes in patients with cardiovascular disease. To date several clinical studies have suggested the potential efficacy of several different stem cell types; however, the benefits seen in clinical trials have been inconsistent and modest. In parallel, preclinical studies have identified key events in the process of cell-based myocardial repair… CONTINUE READING

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