Genetic enhancement of learning and memory in mice

@article{Tang1999GeneticEO,
  title={Genetic enhancement of learning and memory in mice},
  author={Ya-ping Tang and Eiji Shimizu and Gilles R. Dub{\'e} and Claire Rampon and Geoffrey A. Kerchner and Min Zhuo and Guosong Liu and Joe Z. Tsien},
  journal={Nature},
  year={1999},
  volume={401},
  pages={63-69}
}
Hebb's rule (1949) states that learning and memory are based on modifications of synaptic strength among neurons that are simultaneously active. This implies that enhanced synaptic coincidence detection would lead to better learning and memory. If the NMDA (N-methyl-D-aspartate) receptor, a synaptic coincidence detector, acts as a graded switch for memory formation, enhanced signal detection by NMDA receptors should enhance learning and memory. Here we show that overexpression of NMDA receptor… 

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