Genetic enhancement of learning and memory in mice

@article{Tang1999GeneticEO,
  title={Genetic enhancement of learning and memory in mice},
  author={Ya-ping Tang and Eiji Shimizu and Gilles R. Dube and Claire Rampon and Geoffrey A. Kerchner and Min Zhuo and Guosong Liu and Joe Z. Tsien},
  journal={Nature},
  year={1999},
  volume={401},
  pages={63-69}
}
Hebb's rule (1949) states that learning and memory are based on modifications of synaptic strength among neurons that are simultaneously active. This implies that enhanced synaptic coincidence detection would lead to better learning and memory. If the NMDA (N-methyl-D-aspartate) receptor, a synaptic coincidence detector, acts as a graded switch for memory formation, enhanced signal detection by NMDA receptors should enhance learning and memory. Here we show that overexpression of NMDA receptor… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 851 CITATIONS

FILTER CITATIONS BY YEAR

1999
2019

CITATION STATISTICS

  • 76 Highly Influenced Citations

  • Averaged 35 Citations per year over the last 3 years

  • 5% Increase in citations per year in 2018 over 2017

References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

Similar Papers

Loading similar papers…