Genetic enhancement of inflammatory pain by forebrain NR2B overexpression

@article{Wei2001GeneticEO,
  title={Genetic enhancement of inflammatory pain by forebrain NR2B overexpression},
  author={Feng Wei and Guo-Du Wang and Geoffrey A. Kerchner and Susan Kim and Hai-Ming Xu and Zhou-feng Chen and Min Zhuo},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={164-169}
}
N-methyl-D-aspartate (NMDA) receptors contribute to many brain functions. We studied the effect of forebrain-targeted overexpression of the NMDA receptor subunit NR2B on the response of mice to tissue injury and inflammation. Transgenic mice exhibited prominent NR2B expression and enhanced NMDA receptor-mediated synaptic responses in two pain-related forebrain areas, the anterior cingulate cortex and insular cortex, but not in the spinal cord. Although transgenic and wild type mice were… CONTINUE READING
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