Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene

@article{Baltzer2000GeneticEO,
  title={Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene},
  author={Axel W. A. Baltzer and Christian Lattermann and Janey D. Whalen and Paul H. Wooley and K. Ft. Weiss and M. -O. Grimm and S C. Ghivizzani and P. David Robbins and Christopher H. Evans},
  journal={Gene Therapy},
  year={2000},
  volume={7},
  pages={734-739}
}
This study evaluated the ability of gene transfer to enhance bone healing. Segmental defects were created surgically in the femora of New Zealand white rabbits. First generation adenoviruses were used as vectors to introduce into the defects genes encoding either human bone morphogenetic protein-2 (BMP-2) or, as a negative control, firefly luciferase. Representative specimens were evaluated histologically after 8 weeks. Healing of the defects was monitored radiographically for 12 weeks, after… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 90 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

The effect of regional gene therapy with bone morphogenetic protein-2 producing bone-marrow cells on the repair of segmental femoral defects in rats

  • JR Lieberman
  • J Bone Joint Surg
  • 1999

Expression of human bone morphogenetic protein 7 in primary rabbit periosteal cells: potential utility in gene therapy for osteochondral repair

  • JM Mason
  • Gene Therapy
  • 1998

Similar Papers

Loading similar papers…